ECO24: Pilot Study Finds Very Low-Calorie Ketogenic Diet Improved Acne and Quality of Life What are the main findings?

Response:  The study recruited 31 young women with treatment-naïve moderate acne and grade I obesity, who adhered to a 45-day active phase of VLCKD. Results showed significant improvements in anthropometric parameters, body composition, and acne severity, as measured by the Global Acne Grading System (GAGS) score. Additionally, quality of life, as assessed by the Dermatology Life Quality Index (DLQI), also significantly improved. These improvements correlated with reductions in markers of inflammation (TMAO and dROMs) and oxidative stress, along with an increase in phase angle (PhA), a marker of cell membrane integrity. What should readers take away from your report?

Response: The 45-day active phase of VLCKD led to notable improvements in acne severity and quality of life among young women with moderate acne and obesity. These improvements were associated with the known antioxidant and anti-inflammatory effects of the VLCKD. This suggests that dietary interventions, particularly VLCKD, could offer safe and effective adjunctive treatments for acne, potentially reducing reliance on medications with potential side effects. What recommendations do you have for future research as a results of this study?

Response: Further investigation is needed to confirm and expand upon these findings, including studies with larger sample sizes and longer intervention periods to assess the sustainability of VLCKD effects on acne. Additionally, exploring the mechanisms underlying the observed improvements, such as changes in gut microbiota composition and metabolic pathways, could provide valuable insights. Comparative studies with other dietary interventions and standard acne treatments would also be beneficial for understanding the relative efficacy and safety of very low-calorie ketogenic diet.

The study did not disclose any conflicts of interest.

Citation: Abstract presented at the European Congress on Obesity 2024

Very Low-Calorie Ketogenic Diet (VLCKD): A Therapeutic Nutritional Tool for Acne? Results of a Pilot Study Luigi Barrea, Ludovica Verde, Mattia Proganò, Giuseppe Annunziata, Silvia Savastano, Annamaria Colao, Giovanna Muscogiuri

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