FightAcne.com Interview with: Prof. Miriam Santer Professor of Primary Care Research Primary Care Research Centre School of Primary Care, Population Sciences and Medical Education (PPM) Faculty of Medicine University of Southampton, Southampton
FightAcne.com: What is the background for this study?
Response: Spironolactone has been used for the treatment of acne in women for many years, but with surprisingly little evidence from randomised trials regarding its effectiveness. This lack of evidence meant that, although it was in some national prescribing guidelines, it wasn’t in most guidelines, leading to uncertainty amongst prescribers and frustration for women trying to access this treatment.
Jonathan S. Dosik, MD Principal Investigator TKL Research, Inc. Fair Lawn, New Jersey
FightAcne.com: What is the background for this study?
Response: Bacterial biofilms are communities of bacteria that adhere to a wide variety of surfaces, held together by polymer matrices composed of polysaccharides, secreted proteins, and extracellular DNA. Biofilms may penetrate into the sebum and act as an adhesive, promoting formation of microcomedones. On the skin, bacteria adhere to the surface of the pilosebaceous unit, secreting a protective physical polysaccharide barrier which provides resistance to antimicrobial therapies. Resistance to conventional antimicrobial treatment is not only due to the physical barrier created by the rapidly established biofilm, but also the expression of hundreds of new proteins. These proteins facilitate biofilm development by enabling bacterial surface attachment as well as clustering and secretion of extracellular polysaccharides.
Next Science, LLC. has developed acne cream products with formulations based on a material science approach which target both the biofilm and the bacteria entrenched within. This novel biofilm eradicating technology attacks biofilms in three ways:
Breaks the ionic bridges that hold the biofilm together,
Solubilizes the individual polymers, exposing the bacteria,
FightAcne.com Interview with: Jerry Tan, MD Western University Canada Schulich School of Medicine and Dentistry Windsor, Ontario, Canada
Dr. Tan
FightAcne.com: What is the background for this study? What are the main findings?
Response: Acne was personified as an unwanted intruder responsible for negative self-image and emotional impairment
FightAcne.com: What should readers take away from your report?
Response: The burden of acne can extend across long durations of life (adolescence to adulthood),
Scarring Acne: DermNet image
With acne scarring, this adverse impact persists along with a expressions of resignation and acceptance.
Disclosures: Advisor, consultant, speaker and/or trialist for Bausch, Boots Walgreens, Cipher, Cutera, Galderma, L’Oreal, Pfizer, Novartis, Sun
Citation:
Tan J, Chavda R, Leclerc M, Dréno B. Projective Personification Approach to the Experience of People With Acne and Acne Scarring—Expressing the Unspoken. JAMA Dermatol. Published online July 20, 2022. doi:10.1001/jamadermatol.2022.2742
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FightAcne.com Interview with: John S. Barbieri, M.D., M.B.A. University of Pennsylvania Perelman School of Medicine Philadelphia Now practicing at: Brigham and Women’s Hospital
Dr. Barbieri
FightAcne.com: What is the background for this study?
Response: Nearly 50% of women experience acne in their 20s and 35% experience acne in their 30s. While several qualitative studies have examined acne in adolescence, the lived experience of adult female acne has not been explored in detail.
As a result, we conducted a series of semi-structured interviews among 50 adult women with acne to examine the lived experience of adult acne and its treatment.
