CGRP Inhibitors, Used to Treat Migraines, May Be Helpful in Acne and Rosacea

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FightAcne.com Interview with:
Christopher J. Thang, BS
John Sealy School of Medicine
The University of Texas Medical Branch, Galveston
Department of Dermatology
Massachusetts General Hospital
Harvard Medical School, Boston

Jenny Lai, PhD
Harvard Medical School,
Department of Dermatology
Brigham and Women’s Hospital
Boston, Massachusetts

John S. Barbieri, MD, MBA, Senior Author
Department of Dermatology
Brigham and Women’s Hospital, Boston, Massachusetts
Associate Editor, JAMA Dermatology

FightAcne.com: What is the background for this study?

Response: Calcitonin gene-related peptide (CGRP) mediates neurogenic inflammation and vasodilation. Prior research has demonstrated increased CGRP expression in the skin of rosacea patients who experience flushing. CGRP signaling has also been implicated in acne pathogenesis. CGRP inhibitors are used for the prevention and treatment of migraines. We investigated whether CGRP inhibition for migraine patients is associated with a decreased risk of developing acne or rosacea. 

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ECO24: Pilot Study Finds Very Low-Calorie Ketogenic Diet Improved Acne and Quality of Life

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FightAcne.com Interview with:

Dr. Ludovica Verde, PhD
Student at the Department of Public Health
University of Naples Federico II, Italy

Prof. Luigi Barrea
Associate Professor of Clinical Nutrition and Dietetics
Department of Wellbeing, Nutrition and Sport
Università Telematica Pegaso, Naples, Italy.


FightAcne.com: What is the background for this study?

Response: The study focuses on acne, a chronic inflammatory skin condition often associated with obesity due to shared mechanisms of inflammation and oxidative stress. While the impact of diet on acne is inconclusive, the very low-calorie ketogenic diet (VLCKD), known for its anti-inflammatory properties and weight loss effects, holds promise. However, its effects on acne remain underexplored.

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American Academy of Dermatology Updates ACNE Management Guidelines

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Updates recommendations for benzoyl peroxide, topical retinoids, topical antibiotics, and oral doxycycline and oral isotretinoin as well as conditional recommendations for newer medications topical clascoterone, salicylic acid, and azelaic acid, as well as for oral minocycline, combined oral contraceptive pills, and spironolactone.

https://www.jaad.org/article/S0190-9622(23)03389-3/fulltext

Scientists Attempt to Fight Acne With Skin Bacteria Engineered to Deliver Treatment

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FightAcne.com Interview with:
Nastassia Knödlseder PhD (She/Her)
Postdoctoral Researcher
Department of Medicine and Life Sciences (MELIS)
Pompeu Fabra University in Barcelona

FightAcne.com: What is the background for this study?

Response: Cutibacterium acnes is the most abundant commensal of the human skin. It inhabits the pilosebaceous units of the hair follicles where it feeds from sebum. This niche environment is of great interest since it is located deep inside the dermis close to interesting dermatological targets.

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More Education and Better Strategies Needed to Fight Acne in Transgender Individuals

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FightAcne.com Interview with:
Howa Yeung, MD MSc | He/him
Assistant Professor of Dermatology
Emory University School of Medicine

FightAcne.com: What is the background for this study?

Response: Acne is common in transgender and gender diverse individuals who receive gender-affirming hormone therapy – a health disparity population that is understudied in health research. We aimed to explore the impact of acne and identify practice gaps in acne treatment in transgender and gender diverse individuals.

FightAcne.com: What are the main findings?

Response:  Acne led to experiences of rejection and discrimination, worsened body dissatisfaction, and led to social avoidance. Transgender women reported acne interfering with feminine gender expression. Transgender men often normalized acne development, sometimes positively as an early sign of testosterone action. Many tried over-the-counter treatments and sought advice from physicians, peers, online forums, and social media.

Barriers to acne treatments included cost, lack of multidisciplinary care, mistrust toward the health care system, and lack of transgender-specific acne care education. Isotretinoin treatment required navigation of potential mental health adverse effects and patient discomfort with contraceptive and pregnancy testing requirements.

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Double Blind Study Finds Spironolactone Effective in Fighting Acne

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FightAcne.com Interview with:
Prof. Miriam Santer
Professor of Primary Care Research
Primary Care Research Centre
School of Primary Care, Population Sciences and Medical Education (PPM)
Faculty of Medicine
University of Southampton, Southampton

FightAcne.com: What is the background for this study?

Response: Spironolactone has been used for the treatment of acne in women for many years, but with surprisingly little evidence from randomised trials regarding its effectiveness. This lack of evidence meant that, although it was in some national prescribing guidelines, it wasn’t in most guidelines, leading to uncertainty amongst prescribers and frustration for women trying to access this treatment.

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Colorism Can Lead to Use of Potentially Harmful Skin Lightening Products

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FightAcne.com Interview with:
Roopal V Kundu, MD
Associate Dean for Admissions
Jacob R. Suker, MD, Professor of Medical Education
Professor of Dermatology (Medical Dermatology and Medical Education

FightAcne.com: What is the background for this study? What is ‘colorism”

Response: The study stemmed from patient interactions in clinics where some patients were coming in requesting to lighten their skin. In trying to understand this better, we learned that colorism – a type of shadeism – in which people of a certain ethnic group are treated differently based on their darker skin color – was a psychosocial and socio-cultural factor effecting skin tone preferences.

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Study Evaluates Effect of a Biofilm Disrupting Acne Cream on Mild-to-Moderate Facial Acne

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Jonathan S. Dosik, MD
Principal Investigator
TKL Research, Inc.
Fair Lawn, New Jersey

FightAcne.com: What is the background for this study?

Response: Bacterial biofilms are communities of bacteria that adhere to a wide variety of surfaces, held together by polymer matrices composed of polysaccharides, secreted proteins, and extracellular DNA.  Biofilms may penetrate into the sebum and act as an adhesive, promoting formation of microcomedones.  On the skin, bacteria adhere to the surface of the pilosebaceous unit, secreting a protective physical polysaccharide barrier which provides resistance to antimicrobial therapies. Resistance to conventional antimicrobial treatment is not only due to the physical barrier created by the rapidly established biofilm, but also the expression of hundreds of new proteins.  These proteins facilitate biofilm development by enabling bacterial surface attachment as well as clustering and secretion of extracellular polysaccharides.

Next Science, LLC. has developed acne cream products with formulations based on a material science approach which target both the biofilm and the bacteria entrenched within. This novel biofilm eradicating technology attacks biofilms in three ways:

  1. Breaks the ionic bridges that hold the biofilm together,
  2. Solubilizes the individual polymers, exposing the bacteria,
  3. Directly kills bacteria by cell lysis.
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Effects of Acne and Acne Scarring Can Last Decades

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FightAcne.com Interview with:
Jerry Tan, MD
Western University Canada
Schulich School of Medicine and Dentistry
Windsor, Ontario, Canada

Dr. Tan

FightAcne.com:  What is the background for this study?  What are the main findings?

Response: Acne was personified as an unwanted intruder responsible for negative self-image and emotional impairment

FightAcne.com: What should readers take away from your report?

Response: The burden of acne can extend across long durations of life (adolescence to adulthood),

Scarring Acne: DermNet image

With acne scarring, this adverse impact persists along with a expressions of resignation and acceptance.

Disclosures: Advisor, consultant, speaker and/or trialist for Bausch, Boots Walgreens, Cipher, Cutera, Galderma, L’Oreal, Pfizer, Novartis, Sun



Citation:

Tan J, Chavda R, Leclerc M, Dréno B. Projective Personification Approach to the Experience of People With Acne and Acne Scarring—Expressing the Unspoken. JAMA Dermatol. Published online July 20, 2022. doi:10.1001/jamadermatol.2022.2742

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Acne Scars: Trial Tests Microneedling With Insulin and Vitamin C

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FightAcne.com Interview with:
Mohamed L. Elsaie, MD
Senator at the Egyptian Senate
Professor of Dermatology, NRC, Egypt
Fellow of the University of Miami; USA

Prof. Elsaie

FightAcne.com:  What is the background for this study? 

Response: Post acne scars following sebaceous injury and abnormal wound healing during the course of acne is a prevalent and challenging to treat condition To evaluate microneedling by dermapen with topical vitamin C versus microneedling with topical insulin in treating atrophic post-acne scars.

A split-face comparative study included 30 subjects with atrophic post-acne scars. Human insulin was topically applied to the left side of the face and on the right side, vitamin C serum was applied.

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